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Contrarily, local application of estrogen has been shown to block the ability of to slow serotonin clearance, suggesting that the same pathways which are involved in SSRI efficacy may also be affected by components of local estrogen signaling pathways.

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If you decide to go for a cycle first (which I advise against before knowing) then at least go get your levels checked about 6-8 wks after your cycle to see if PCT is bringing you back.

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